上海
*僅供醫學專業人士閱讀參考
埃萬妥單抗聯合蘭澤替尼方案正式獲得NMPA批準，成為中國EGFR敏感突變晚期非小細胞肺癌一線治療新增選擇。
*以下內容僅供醫療衛生專業人士瀏覽。
參考文獻：
[1]Cho BC, Lu S, Felip E, et al. Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC. N Engl J Med. 2024;391(16):1486-1498.
[2]Lu S, Byoung CC, Jong-Seok L, et al. Amivantamab Plus Lazertinib vs Osimertinib as First-line Treatment Among Asian Patients With EGFR-mutated, Advanced Non-small Cell Lung Cancer (NSCLC): MARIPOSA Subgroup Analysis. 2023 ESMO Aisa. LBA10.
[3]Cho BC, Lu S, Felip E, et al. Amivantamab plus lazertinib vs osimertinib in first-line (1L) EGFR-mutant (EGFRm) advanced NSCLC: Final overall survival (OS) from the phase III MARIPOSA study. 2025 ELCC. 4O.
[4]NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines?) Non-Small cell LungCancer Version 7.2025.
[5]中國臨床腫瘤學會（CSCO）非小細胞肺癌（NSCLC）診療指南（2025年）
[6]Cho BC, Lu S, Felip E, et al. Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC. N Engl J Med. 2024;391(16):1486-1498.
[7]Spira AI, Paz-Ares L, Han JY, et al. Preventing Infusion-Related Reactions With Intravenous Amivantamab-Results From SKIPPirr,a Phase 2 Study:A Brief Report.J Thorac Oncol. Published online January 24,2025.
[8]Nicolas G, Li WM, Alexander lS, et al.Preventing moderate to severe dermatologic adverse events in first-line EGFR-mutant advanced NSCLC treated with amivantamab plus lazertinib:Early success of the COCOON trial.2025 ELCC. 10MO.
[9]Feldman JL, Cho BC, Li W, et al. Dermatologic prophylaxis and impact on patient-reported outcomes in first-line EGFR-mutant advanced NSCLC treated with amivantamab plus lazertinib: Results from the phase 2 COCOON trial. 2025 ASCO. Abstract 8641.
審批編號：CP-551633 審批時間：11/11/2025 過期時間：11/11/2026
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